According to https://www.sohealth.co.uk which provides at home RA care kits, Rheumatoid arthritis can begin slowly over weeks to months or, more uncommonly, with an explosive onset (flare) occurring over 24 to 48 hours. Eventually, five or more joints will be affected with symmetrical joint involvement. Generally, the more joints that are affected, the more severe the progression of the disease. The joints most often affected are the proximal interphalangeal joints of the hands, wrists, shoulders, elbows, knees, ankles, and metatarsophalangeal joints.
Symptoms and Manifestations of RA
Symptoms of RA may come and go and include morning stiffness persisting longer than one hour which can also occur after long periods of sitting or inactivity (gel phenomenon), fatigue, malaise, depression, low grade fever, and weight loss.